Article

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

2024-02-14

Abstract excerpt

<h4>ABSTRACT</h4> Immune system control is a major hurdle that cancer evolution must circumvent. The relative timing and evolutionary dynamics of subclones that have escaped immune control remain incompletely characterized, and how immune-mediated selection shapes the epigenome has received little attention. Here, we infer the genome- and epigenome-driven evolutionary dynamics of tumour-immune coevolution within...

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Literature Corpus work: 7fb5c799-b00f-55e6-aef7-570bfa8fcc73
DOI: 10.1101/2024.02.12.579956

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