Article

Causal dynamical modelling predicts novel regulatory genes of FOXP3 in human regulatory T cells

2020-02-14

Abstract excerpt

Regulatory T cells (Tregs), characterized as a CD4+CD25+FOXP3+ subset of T cells, are vital to the induction of immune tolerance and the maintenance of immune homeostasis. While target genes of Treg master regulator FOXP3 have been identified, the upstream regulatory machinery of FOXP3 still remains largely unknown. Here we dynamically model causal relationships among genes from available time-series genome-scale...

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Literature Corpus work: cae717ee-23c1-5289-bfb0-1933066d5f89
DOI: 10.1101/2020.02.13.943688

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