A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases.

doi:10.1126/scitranslmed.aad2722

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Article

A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases.

Science translational medicine - 11 Nov 2015

Gustafsson Mika, Gawel Danuta R, Alfredsson Lars, Baranzini Sergio, Björkander Janne, Blomgran Robert, Hellberg Sandra, Eklund Daniel, Ernerudh Jan, Kockum Ingrid, Konstantinell Aelita, Lahesmaa Riita, Lentini Antonio, Liljenström H Robert I, Mattson Lina, Matussek Andreas, Mellergård Johan, Mendez Melissa, Olsson Tomas, Pujana Miguel A, Rasool Omid, Serra-Musach Jordi, Stenmarker Margaretha, Tripathi Subhash, Viitala Miro, Wang Hui, Zhang Huan, Nestor Colm E, Benson Mikael

Abstract excerpt

Early regulators of disease may increase understanding of disease mechanisms and serve as markers for presymptomatic diagnosis and treatment. However, early regulators are difficult to identify because patients generally present after they are symptomatic. We hypothesized that early regulators of T cell-associated diseases could be found by identifying upstream transcription factors (TFs) in T cell...

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PMID: 26560356
DOI: 10.1126/scitranslmed.aad2722

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GATA3
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