Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Different molecular complexes that mediate transcriptional induction and repression by FoxP3.

Nature immunology - 1 Nov 2017

Kwon Ho-Keun, Chen Hui-Min, Mathis Diane, Benoist Christophe

Abstract excerpt

FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells (Treg cells). Its mechanism of action, whether as an activator or a repressor, has remained unclear. Here, chromatin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci over- or under-expressed in Treg cells. We evaluated the impact of a panel of FoxP3 mutants on its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Forkhead Transcription Factors
Share to Histone Acetyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Histone Methyltransferases

Share to Immunoblotting

Share to NIH 3T3 Cells

Share to T-Lymphocytes, Regulatory

Share to Transcription Factor RelA

Source

Open in PubMed Open full text

Identifiers

PMID: 28892470
DOI: 10.1038/ni.3835
PMCID: PMC5679728

Genes

IKZF2
IKZF3
KAT5
RELA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different molecular complexes that mediate transcriptional induction and repression by FoxP3.PMID 28892470Read ↗

Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.Semantic proximity Read ↗

Multidomain Coupling Governs FoxP1 Assembly and Nuclear CompartmentalizationSemantic proximity Read ↗

Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity and tumor immunity by disrupting the associationSemantic proximity Read ↗

The splicing isoform Foxp3Δ2 releases the autoinhibitory conformation and differentially regulates tTregs and pTregs homeostasisSemantic proximity Read ↗

FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.Semantic proximity Read ↗

FoxP3 enhances HIV-1 gene expression by modulating NFkappaB occupancy at the long terminal repeat in human T cells.Semantic proximity Read ↗

Transcriptional control of regulatory T-cell differentiation.Semantic proximity Read ↗

Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.Semantic proximity Read ↗

FOXP3: genetic and epigenetic implications for autoimmunity.Semantic proximity Read ↗

Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3Semantic proximity Read ↗

Structural insights into FOXP2 multimerization and interactions from AlphaFold3 modelingSemantic proximity Read ↗

FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.