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Article

From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics.

Clinical and experimental immunology - 1 Jul 2019

Bending D, Ono M

Abstract excerpt

Studies on regulatory T cells (Treg ) have focused on thymic Treg as a stable lineage of immunosuppressive T cells, the differentiation of which is controlled by the transcription factor forkhead box protein 3 (Foxp3). This lineage perspective, however, may constrain hypotheses regarding the role of Foxp3 and Treg in vivo, particularly in clinical settings and immunotherapy development. In this review, we...

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Share to Cell Lineage
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to T-Lymphocytes, Regulatory

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Identifiers

PMID: 30076771
DOI: 10.1111/cei.13194
PMCID: PMC6591142

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