Article

The splicing isoform Foxp3Δ2 releases the autoinhibitory conformation and differentially regulates tTregs and pTregs homeostasis

2023-01-09

Abstract excerpt

<h4>Summary</h4> Foxp3 is the master transcription factor for the development and function of regulatory T cells (Tregs). So far, little is known about whether the conformation change in Foxp3 could impact the Tregs biology. Alternative splicing of human Foxp3 results in the expression of two major isoforms: the full-length protein or an exon 2-deleted protein (Foxp3Δ2). Here, AlphaFold2 structure predictions and...

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Literature Corpus work: aa341622-1939-575c-8716-7f30ab57ccfd
DOI: 10.1101/2023.01.09.523191

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