Article

Differential Regulation of Large-scale Chromosome Conformations in Osteoblasts and Osteosarcoma

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Correct chromosome organization in the cell nucleus is essential for genome function. However, dynamics and regulations of large-scale chromosomal conformations beyond single compartments at larger than ten megabases in vivo in single cells remain largely unknown. Here we use CRISPR-Sirius, a high-resolution and high-sensitivity real-time imaging technique, to directly visualize distinctions in...

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Literature Corpus work: 8a7b4fbc-c644-5d8c-a372-1ef4c4b2ad4a
DOI: 10.1101/2024.11.01.621571

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