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Combinatorial organoid mutagenesis screen reveals gene constellations driving malignant transformation, pathology and chemosensitivity in high-grade serous ovarian carcinoma

2025-03-13

Abstract excerpt

High-grade serous ovarian carcinoma (HGSC) is the sixth leading cause of cancer-related death among women. Many cases arise from the Fallopian tubal epithelium (TE), exhibit numerous mutations, and present heterogenous pathological features. However, the contribution of specific mutation combinations to cellular transformation, pathological phenotype and chemotherapeutic response remains poorly understood. Here, w...

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Literature Corpus work
cabb4cbc-49ab-5eb1-80ea-d2e9fe9623bc
DOI
10.1101/2025.03.10.642422
Open publication

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