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Multiplex organoid mutagenesis reveals gene combinations driving transformation, pathology, and chemosensitivity in ovarian carcinoma.

Genetics - 3 Jun 2026

Phuong Daryl J, Ralston Coulter Q, Ezzat Tony M, Ashe Christopher S, Armstrong Amanda P, Flesken-Nikitin Andrea, Yamulla Robert J, Nikitin Alexander Yu, Schimenti John C

Abstract excerpt

High-grade serous ovarian carcinoma (HGSC) is the sixth leading cause of cancer-related death among women. Most tumors arise from the Fallopian tubal epithelium (TE), exhibit numerous mutations, and present heterogenous pathological features. However, the contribution of specific mutation combinations to cellular transformation, pathological phenotype, and chemotherapeutic responses remains unclear. We used a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41986871
DOI: 10.1093/genetics/iyag098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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