Article
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.
Nature communications - 27 May 2020
Lõhmussaar Kadi, Kopper Oded, Korving Jeroen, Begthel Harry, Vreuls Celien P H, van Es Johan H, Clevers Hans
Abstract excerpt
High-grade serous ovarian cancer (HG-SOC)-often referred to as a "silent killer"-is the most lethal gynecological malignancy. The fallopian tube (murine oviduct) and ovarian surface epithelium (OSE) are considered the main candidate tissues of origin of this cancer. However, the relative contribution of each tissue to HG-SOC is not yet clear. Here, we establish organoid-based tumor progression models of HG-SOC...
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