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Article

Murine cell lines with defined mutations model different histological subtypes of epithelial ovarian cancer.

Disease models & mechanisms - 1 Jul 2025

Zhang Lixin, Fang Yusi, Uygun Ibrahim, Li Danyang, Strange Mary, Zaidi Syed K, Wang Wenjia, Knight Julia, Radolec Mackenzy, Elishaev Esther, Brozick Joan F, Edwards Allison, Tseng George, Cascio Sandra, Buckanovich Ronald, Edwards Robert P, Vlad Anda M

Abstract excerpt

Preclinical modeling of epithelial ovarian cancer in immune-competent mice progressing to orthotopic, spontaneous tumors is challenging, requiring multiple genetic modifications in the host. Transplantable models using cell lines are easier to implement than spontaneous animal models, given that they reproduce the key disease characteristics. To create new in vivo ovarian tumor models, we generated 28 murine...

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Share to Carcinoma, Ovarian Epithelial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Mice, Inbred C57BL

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Share to Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 40642792
DOI: 10.1242/dmm.052177
PMCID: PMC12352289

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