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Article

Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation.

Cell reports - 1 Sept 2020

Yamulla Robert Joseph, Nalubola Shreya, Flesken-Nikitin Andrea, Nikitin Alexander Yu, Schimenti John C

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is the fifth leading cause of cancer-related deaths of women in the United States. Disease-associated mutations have been identified by the Cancer Genome Atlas Research Network. However, aside from mutations in TP53 or the RB1 pathway that are common in HGSOC, the contributions of mutation combinations are unclear. Here, we report CRISPR mutagenesis of 20 putative HGSOC...

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Source

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Identifiers

PMID: 32877668
DOI: 10.1016/j.celrep.2020.108086
PMCID: PMC7545232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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