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Transforming cancer treatment: integrating patient-derived organoids and CRISPR screening for precision medicine

25 Mar 2025

Abstract excerpt

The persistently high mortality rates associated with cancer underscore the imperative need for innovative, efficacious, and safer therapeutic agents, as well as a more nuanced understanding of tumor biology. Patient-derived organoids (PDOs) have emerged as innovative preclinical models with significant translational potential, capable of accurately recapitulating the structural, functional, and heterogeneous...

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PMID: 40201690
DOI: 10.3389/fphar.2025.1563198

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