Article
A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2023
Chen Jingyao, Dai Siqi, Zhao Lei, Peng Yiman, Sun Chongen, Peng Hongling, Zhong Qian, Quan Yuan, Li Yue, Chen Xuelan, Pan Xiangyu, Zhong Ailing, Wang Manli, Zhang Mengsha, Yang Shengyong, Lu You, Lian Zhong, Liu Yu, Zhou Shengtao, Li Zhengyu, Na Feifei, Chen Chong
Abstract excerpt
Endometrial cancer (EC) is the most common female reproductive tract cancer and its incidence has been continuously increasing in recent years. The underlying mechanisms of EC tumorigenesis remain unclear, and efficient target therapies are lacking, for both of which feasible endometrial cancer animal models are essential but currently limited. Here, an organoid and genome editing-based strategy to generate...
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