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Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer

2020-04-07

Abstract excerpt

<h4>SUMMARY</h4> The paucity of genetically informed, immune-competent tumor models impedes evaluation of conventional, targeted, and immune therapies. By engineering mouse fallopian tube (FT) organoids using lentiviral gene transduction and/or CRISPR/Cas9 mutagenesis, we generated multiple high grade serous ovarian carcinoma (HGSOC) models exhibiting mutational combinations seen in patients. Detailed analysis of...

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Literature Corpus work
63cb0376-c095-561f-ac56-72308afe6641
DOI
10.1101/2020.04.06.028597
Open publication

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Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian CancerDOI 10.1101/2020.04.06.028597
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