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Article

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma.

Nature communications - 26 Nov 2019

Zhang Shuang, Dolgalev Igor, Zhang Tao, Ran Hao, Levine Douglas A, Neel Benjamin G

Abstract excerpt

The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial, with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered candidates. Here, by using genetically engineered mouse models and organoids, we assessed the tumor-forming properties of FTE and OSE harboring the same oncogenic abnormalities. Combined RB family inactivation and Tp53 mutation in...

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Identifiers

PMID: 31772167
DOI: 10.1038/s41467-019-13116-2
PMCID: PMC6879755

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