Article

MYC is sufficient to generate mid-life high-grade serous ovarian and uterine serous carcinomas in a p53-R270H mouse model

2024-01-29

Abstract excerpt

Genetically engineered mouse models (GEMM) have fundamentally changed how ovarian cancer etiology, early detection, and treatment is understood. However, previous GEMMs of high-grade serous ovarian cancer (HGSOC) have had to utilize genetics rarely or never found in human HGSOC to yield ovarian cancer within the lifespan of a mouse. MYC , an oncogene, is amongst the most amplified genes in HGSOC, but it has not p...

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Literature Corpus work: ec0847b4-129a-591f-aab4-799026bc12d5
DOI: 10.1101/2024.01.24.576924

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