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Most commonly mutated genes in High Grade Serous Ovarian Carcinoma are nonessential for ovarian surface epithelial stem cell transformation

2020-01-28

Abstract excerpt

High grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer and the 5 th leading cause of cancer-related deaths of women in the USA. Disease-associated mutations have been identified by the Cancer Genome Atlas Research Network. However, aside from mutations in TP53 or alterations in the RB1 pathway that are extremely common in HGSOC, the contributions of other mutation combinations have...

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Literature Corpus work
76839a65-dca5-525b-8ee0-108879c301f3
DOI
10.1101/2020.01.27.921718
Open publication

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Most commonly mutated genes in High Grade Serous Ovarian Carcinoma are nonessential for ovarian surface epithelial stem cell transformationDOI 10.1101/2020.01.27.921718
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