Article

DNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos

2024-02-08

Abstract excerpt

<h4>ABSTRACT</h4> DNA methylation (DNAme) serves a stable gene regulatory function in somatic cells (1). In the germ line and during early embryogenesis, however, DNAme undergoes global erasure and re-establishment to support germ cell and embryonic development (2). While de novo DNAme acquisition during male germ cell development is essential for setting genomic DNA methylation imprints, other intergenerational...

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Literature Corpus work: caae0b15-5d48-5000-8dc1-669a95941459
DOI: 10.1101/2024.02.06.579069

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