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Article

Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo.

Nature communications - 27 Oct 2020

Richard Albert Julien, Au Yeung Wan Kin, Toriyama Keisuke, Kobayashi Hisato, Hirasawa Ryutaro, Brind'Amour Julie, Bogutz Aaron, Sasaki Hiroyuki, Lorincz Matthew

Abstract excerpt

De novo DNA methylation (DNAme) during mammalian spermatogenesis yields a densely methylated genome, with the exception of CpG islands (CGIs), which are hypomethylated in sperm. While the paternal genome undergoes widespread DNAme loss before the first S-phase following fertilization, recent mass spectrometry analysis revealed that the zygotic paternal genome is paradoxically also subject to a low level of de...

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Source

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Identifiers

PMID: 33110091
DOI: 10.1038/s41467-020-19279-7
PMCID: PMC7591512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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