Article

KDM6A/UTX promotes spermatogenic gene expression across generations but is dispensable for male fertility

2022-10-27

Abstract excerpt

Paternal chromatin undergoes extensive structural and epigenetic changes during mammalian spermatogenesis, producing sperm that contain an epigenome optimal for the transition to embryogenesis. Histone modifiers play an important role in this process by encoding specialized regulatory information in the sperm epigenome. Lysine demethylase 6a (KDM6A) promotes gene activation via demethylation of H3K27me3, a develop...

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Literature Corpus work: 577d5cb4-23b0-53af-89b4-0cfd61778a8a
DOI: 10.1101/2022.10.27.513976

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