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Site-specific DNA demethylation during spermatogenesis presets the sites of nucleosome retention in mouse sperm

2025-01-11

Abstract excerpt

DNA methylation patterns are inherited from the parental germline to the embryo. In mature sperm, the sites of unmethylated DNA are tightly coupled to sites of histone retention at gene regulatory elements that are implicated in paternal epigenetic inheritance. The timing and mechanism of site-specific DNA demethylation in the male germline currently remains unknown. Here, we perform genome-wide profiling of DNA m...

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Literature Corpus work
d3ea90aa-25c8-5194-afa5-31df2b83876f
DOI
10.1101/2025.01.10.632457
Open publication

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Site-specific DNA demethylation during spermatogenesis presets the sites of nucleosome retention in mouse spermDOI 10.1101/2025.01.10.632457
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