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Article

Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance.

Nucleic acids research - 18 Nov 2020

Lismer Ariane, Siklenka Keith, Lafleur Christine, Dumeaux Vanessa, Kimmins Sarah

Abstract excerpt

Advancing the molecular knowledge surrounding fertility and inheritance has become critical given the halving of sperm counts in the last 40 years, and the rise in complex disease which cannot be explained by genetics alone. The connection between both these trends may lie in alterations to the sperm epigenome and occur through environmental exposures. Changes to the sperm epigenome are also associated with...

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Identifiers

PMID: 33068438
DOI: 10.1093/nar/gkaa712
PMCID: PMC7672453

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