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Article

DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination.

Genes & development - 15 Jun 2015

Zamudio Natasha, Barau Joan, Teissandier Aurélie, Walter Marius, Borsos Maté, Servant Nicolas, Bourc'his Déborah

Abstract excerpt

DNA methylation is essential for protecting the mammalian germline against transposons. When DNA methylation-based transposon control is defective, meiotic chromosome pairing is consistently impaired during spermatogenesis: How and why meiosis is vulnerable to transposon activity is unknown. Using two DNA methylation-deficient backgrounds, the Dnmt3L and Miwi2 mutant mice, we reveal that DNA methylation is...

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Identifiers

PMID: 26109049
DOI: 10.1101/gad.257840.114
PMCID: PMC4495397

Genes

DMC1
SPO11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination.PMID 26109049Read ↗

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