Article

Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stress

2018-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic disorders such as obesity and nonalcoholic fatty liver disease (NAFLD) are emerging diseases that affect the global population. One facet of these disorders is attributed to the disturbance of membrane lipid composition. Perturbation of endoplasmic reticulum (ER) homeostasis through changes in membrane phospholipid composition results in activation of the unfolded protein response (UPR...

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Literature Corpus work: c77fd0cd-9048-5d84-aaf0-8db0a7670bd1
DOI: 10.1101/285379

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