Article

A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

2022-08-26

Abstract excerpt

Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through homeostatic mechanisms conserved in nearly all forms of life. As most eukaryotic enzymes for lipid synthesis and desaturation localize on endoplasmic reticulum (ER) membranes, it remains unknown how ER-resident lipids rapidly distribute to plasma membranes (PM). Here we report an exceptionally large and evolutionari...

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Literature Corpus work: 34ad94f8-d3e7-5443-b801-3f2eaf1d1838
DOI: 10.1101/2022.08.25.505359

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