Article
Lipid homeostasis is essential for a maximal ER stress response
22 May 2023
Abstract excerpt
Changes in lipid metabolism are associated with aging and age-related diseases, including proteopathies. The endoplasmic reticulum (ER) is uniquely a major hub for protein and lipid synthesis, making its function essential for both protein and lipid homeostasis. However, it is less clear how lipid metabolism and protein quality may impact each other. Here, we identified let-767 , a putative hydroxysteroid...
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