Article
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011
Thibault Guillaume, Ismail Nurzian, Ng Davis T W
Abstract excerpt
Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the unfolded protein response (UPR), is responsible for maintaining endoplasmic reticulum (ER) homeostasis. The highly conserved Ire1 branch regulates hundreds of gene targets by activating a UPR-specific transcription factor. To understand how the UPR manages ER...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.