Article
Activation of the Unfolded Protein Response by Lipid Bilayer Stress.
Molecular cell - 17 Aug 2017
Halbleib Kristina, Pesek Kristina, Covino Roberto, Hofbauer Harald F, Wunnicke Dorith, Hänelt Inga, Hummer Gerhard, Ernst Robert
Abstract excerpt
The unfolded protein response (UPR) is a conserved homeostatic program that is activated by misfolded proteins in the lumen of the endoplasmic reticulum (ER). Recently, it became evident that aberrant lipid compositions of the ER membrane, referred to as lipid bilayer stress, are equally potent in activating the UPR. The underlying molecular mechanism, however, remained unclear. We show that the most conserved...
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