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Article

Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.

PLoS genetics - 1 Jan 2014

Labunskyy Vyacheslav M, Gerashchenko Maxim V, Delaney Joe R, Kaya Alaattin, Kennedy Brian K, Kaeberlein Matt, Gladyshev Vadim N

Abstract excerpt

Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, inhibiting translation, and increasing expression of chaperones that enhance ER protein folding capacity. Although ER stress and protein aggregation have been implicated in aging, the role of UPR...

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Identifiers

PMID: 24391512
DOI: 10.1371/journal.pgen.1004019
PMCID: PMC3879150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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