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Article

Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy.

Molecular biology of the cell - 15 Aug 2017

Kono Nozomu, Amin-Wetzel Niko, Ron David

Abstract excerpt

Altered cellular lipid composition activates the endoplasmic reticulum unfolded protein response (UPR), and UPR signaling effects important changes in lipid metabolism. Secondary effects on protein folding homeostasis likely contribute to UPR activation, but deletion of the unfolded protein stress-sensing luminal domain of the UPR transducers PERK and IRE1α does not abolish their responsiveness to lipid...

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Identifiers

PMID: 28615323
DOI: 10.1091/mbc.E17-03-0144
PMCID: PMC5555659

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