Article

A <i>pcyt-1</i> Allelic Series Reveals In Vivo Consequences of Reduced Phosphatidylcholine Synthesis in <i>C. elegans</i>

2026-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes and is synthesized in part via the rate-limiting enzyme PCYT1A. In humans, hypomorphic PCYT1A variants cause diverse disorders, including retinal dystrophy, lipodystrophy with fatty liver, and spondylometaphyseal dysplasia. To define how graded reductions in PC synthesis affect organismal physiology, we generated...

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Literature Corpus work: 13d8dbbb-4c05-5c20-ad12-fb35bb98c909
DOI: 10.64898/2026.04.22.720214

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