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Article

Cysteine cross-linking in native membranes establishes the transmembrane architecture of Ire1.

The Journal of cell biology - 2 Aug 2021

Väth Kristina, Mattes Carsten, Reinhard John, Covino Roberto, Stumpf Heike, Hummer Gerhard, Ernst Robert

Abstract excerpt

The ER is a key organelle of membrane biogenesis and crucial for the folding of both membrane and secretory proteins. Sensors of the unfolded protein response (UPR) monitor the unfolded protein load in the ER and convey effector functions for maintaining ER homeostasis. Aberrant compositions of the ER membrane, referred to as lipid bilayer stress, are equally potent activators of the UPR. How the distinct signals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Conformation, alpha-Helical

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Source

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Identifiers

PMID: 34196665
DOI: 10.1083/jcb.202011078
PMCID: PMC8256922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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