Article

Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia

2020-01-31

Abstract excerpt

Increasing evidence suggests a role for interferons (IFNs) in neurodegeneration. Parkinson’s disease (PD) associated kinase LRRK2 has been implicated in IFN type II (IFN) response in infections and nigral neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ still remains unclear. Here, we employed dopaminergic (DA) neurons and microglia differentiated from patient induced pluripotent stem cells to u...

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Literature Corpus work: ca25a5eb-acac-5e3c-ad4e-5e4bfc9cd890
DOI: 10.1101/2020.01.30.925222

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