Article

Pathologic α-Synuclein Species Activate LRRK2 in Pro-Inflammatory Monocyte and Macrophage Responses

2020-05-05

Abstract excerpt

Missense mutations in the LRRK2 gene that lead to LRRK2 kinase hyperactivity can cause Parkinson’s disease (PD). The link between LRRK2 and α-synuclein aggregation in PD remains enigmatic. Numerous reports suggest critical LRRK2 functions in microglial responses. Herein, we find that LRRK2-positive immune cells in the brain represent CD68-positive pro-inflammatory, monocyte-derived macrophages, distinct from micr...

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Literature Corpus work: 697499a2-4073-53d4-ad44-4518a86ffb08
DOI: 10.1101/2020.05.04.077065

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