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Article

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.

Journal of neuroinflammation - 18 Nov 2016

López de Maturana Rakel, Lang Valérie, Zubiarrain Amaia, Sousa Amaya, Vázquez Nerea, Gorostidi Ana, Águila Julio, López de Munain Adolfo, Rodríguez Manuel, Sánchez-Pernaute Rosario

Abstract excerpt

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is mounting evidence of LRRK2 involvement in inflammatory pathways. In a previous study, we described an alteration of the inflammatory response in dermal fibroblasts from PD patients expressing the...

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Source

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Identifiers

PMID: 27863501
DOI: 10.1186/s12974-016-0761-x
PMCID: PMC5116223

Genes

PTGS2
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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