Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation

doi:10.3389/fnins.2020.00376

Article

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation

28 Apr 2020

Abstract excerpt

The multiple hit hypothesis for Parkinson's disease (PD) suggests that an interaction between multiple (genetic and/or environmental) risk factors is needed to trigger the pathology. Leucine-Rich Repeat Kinase 2 (LRRK2) is an interesting protein to study in this context and is the focus of this review. More than 15 years of intensive research have identified several cellular pathways in which LRRK2 is involved,...

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