Article

Distinct and Combined Interferon-ɑ/β-receptor-1 Loss in Neurons and Astrocytes Disrupt Brain Energy Metabolism and Drive Parkinsonian Dementia

2025-08-19

Abstract excerpt

Dysregulated interferon-alpha/beta-receptor 1 (IFNAR1) signaling was recently identified to contribute to the development of sporadic Parkinson’s Disease (PD) into PD with Dementia (PDD). The molecular, cellular, and phenotypic impacts of brain IFNAR1 loss in aging have not been explored in vivo , which may reveal novel disease mechanisms and therapeutic targets. Here it is shown that baseline IFNAR1 expression v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ad9081c-4f17-5a45-865f-01ebe3d1e7f9
DOI: 10.1101/2025.08.14.670043

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct and Combined Interferon-ɑ/β-receptor-1 Loss in Neurons and Astrocytes Disrupt Brain Energy Metabolism and Drive Parkinsonian DementiaDOI 10.1101/2025.08.14.670043Read

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissueSemantic proximity Read

Alzheimer’s disease-specific cytokine secretion suppresses neuronal mitochondrial metabolismSemantic proximity Read

Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s DiseaseSemantic proximity Read

Interferon-γ Elicits Pathological Hallmarks of ALS in Human Motor NeuronsSemantic proximity Read

Glial multicellular programs reveal distinct patient stratification in Parkinson's diseaseSemantic proximity Read

IFNγ alters the aberrant phenotype of α-synuclein-treated microglia reducing the detrimental impact of their secretome on dopaminergic neurons.Semantic proximity Read

Brain-wide alterations revealed by spatial transcriptomic and proteomic analyses in COVID-19 infectionSemantic proximity Read

Multiomic profiling reveals aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microgliaSemantic proximity Read

Promyelocytic Leukemia Protein Promotes Neuroprotection in a mouse model of Alzheimer’s Disease by Modulating the Microglial Inflammatory ResponseSemantic proximity Read

HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's diseaseSemantic proximity Read

PINK1/Parkin-dependent mitophagy mediates astrocytic inflammatory responses to mitochondrial damageSemantic proximity Read