Article
The Interferon-miR-146a-5p-Stat1/Nrf2 Pathway Mediates LRRK2-R1441G-induced M1 over M2 Microglia Activation.
Molecular neurobiology - 14 Mar 2026
Lin Lishan, Luo Junfeng, Wang Xiantao, Saravanan Tanvikhaa, Mercado Gabriela, Li Yucheng, Zhang Ya, Florea Liliana D, Hafner Markus, Pei Zhong, Smith Wanli W
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease with movement disorder. The etiology and molecular pathogenesis of PD are not fully understood. Mutations in the LRRK2 gene are the primary genetic causes of PD and contribute to sporadic PD. Mitochondrial dysfunction and neuroinflammation have been reported in LRRK2-based PD models. However, the molecular mechanisms in LRRK2-linked PD...
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