LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model

Abstract excerpt

Parkinson’s disease (PD) is a progressive, incurable neurodegenerative disorder characterized by the loss of neuromelanin (NM)-containing dopamine neurons (DAn) in the substantia nigra of the midbrain. Non-neuronal cells are increasingly recognized as contributors to PD. We generated human microglia-like cells (hMG) from induced pluripotent stem cells (iPSC) derived from patients with LRRK2 PD-causing mutations,...

Topics

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• Gene Expression
• Induced Pluripotent Stem Cells
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Microglia
• Mutation
• Neuroinflammation and Neurodegeneration Mechanisms
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

9b869fd0-e5a5-5331-be73-2384fb28a20d

DOI

10.1101/2024.10.07.616997