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Article

Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells.

Nature communications - 14 Oct 2020

Panagiotakopoulou Vasiliki, Ivanyuk Dina, De Cicco Silvia, Haq Wadood, Arsić Aleksandra, Yu Cong, Messelodi Daria, Oldrati Marvin, Schöndorf David C, Perez Maria-Jose, Cassatella Ruggiero Pio, Jakobi Meike, Schneiderhan-Marra Nicole, Gasser Thomas, Nikić-Spiegel Ivana, Deleidi Michela

Abstract excerpt

Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pluripotent stem cells carrying LRRK2 G2019S, the most common Parkinson's disease-associated...

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Identifiers

PMID: 33057020
DOI: 10.1038/s41467-020-18755-4
PMCID: PMC7560616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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