Article

Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause Mortality

2020-03-17

Abstract excerpt

<h4>ABSTRACT</h4> While genome-wide association studies have identified susceptibility variants for numerous traits, their combined utility for predicting broad measures of health, such as mortality, remains poorly understood. We used data from the UK Biobank to combine polygenic risk scores (PRS) for 13 diseases and 12 mortality risk factors into sex-specific composite PRS (cPRS). These cPRS were moderately assoc...

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Literature Corpus work: ca236752-74d4-5486-a9b7-16d1594719fb
DOI: 10.1101/2020.03.13.20035527

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