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Genetic predisposition to longer lifespan, lifestyle factors, and all-cause mortality: a 17-year prospective cohort study

2025-08-21

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> We used a genome-wide polygenic lifespan score (PLS) to investigate whether genetic predisposition to a longer lifespan is associated with lower mortality risk and how this association compares with associations between long-term lifestyle factors and mortality. <h4>Methods</h4> A PLS was computed for the Older Finnish Twin Cohort (mean age 57·4 years; 45·2% males; N=5575)....

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Literature Corpus work
b99f5e9a-1e1b-5934-be05-8111466569b3
DOI
10.1101/2025.08.19.25333952
Open publication

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Genetic predisposition to longer lifespan, lifestyle factors, and all-cause mortality: a 17-year prospective cohort studyDOI 10.1101/2025.08.19.25333952
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