Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank.

GeroScience - 1 Aug 2024

Don Janith, Schork Andrew J, Glusman Gwênlyn, Rappaport Noa, Cummings Steve R, Duggan David, Raju Anish, Hellberg Kajsa-Lotta Georgii, Gunn Sophia, Monti Stefano, Perls Thomas, Lapidus Jodi, Goetz Laura H, Sebastiani Paola, Schork Nicholas J

Abstract excerpt

Large-scale genome-wide association studies (GWAS) strongly suggest that most traits and diseases have a polygenic component. This observation has motivated the development of disease-specific "polygenic scores (PGS)" that are weighted sums of the effects of disease-associated variants identified from GWAS that correlate with an individual's likelihood of expressing a specific phenotype. Although most GWAS have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Specimen Banks
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Longevity

Share to Multifactorial Inheritance

Share to Parents

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 38451433
DOI: 10.1007/s11357-024-01107-1
PMCID: PMC11226417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank.PMID 38451433Read ↗

Cancer Diagnosis, Polygenic Risk, and Longevity-Associated VariantsSemantic proximity Read ↗

Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespanSemantic proximity Read ↗

Polygenic Health Index, General Health, Pleiotropy, Embryo Selection and Disease RiskSemantic proximity Read ↗

Polygenic Health Index, General Health, and Pleiotropy: Sibling Analysis and Disease Risk ReductionSemantic proximity Read ↗

Polygenic prediction of human longevity on the supposition of pervasive pleiotropySemantic proximity Read ↗

Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan.Semantic proximity Read ↗

The association of a polygenic lifespan score with the risk of common age-related diseases and mortality.Semantic proximity Read ↗

Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause Mortality.Semantic proximity Read ↗

Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause MortalitySemantic proximity Read ↗

Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives.Semantic proximity Read ↗

Genetic predisposition to longer lifespan, lifestyle factors, and all-cause mortality: a 17-year prospective cohort studySemantic proximity Read ↗

Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.