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Article

Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause Mortality.

American journal of human genetics - 3 Sept 2020

Meisner Allison, Kundu Prosenjit, Zhang Yan Dora, Lan Lauren V, Kim Sungwon, Ghandwani Disha, Pal Choudhury Parichoy, Berndt Sonja I, Freedman Neal D, Garcia-Closas Montserrat, Chatterjee Nilanjan

Abstract excerpt

While genome-wide association studies have identified susceptibility variants for numerous traits, their combined utility for predicting broad measures of health, such as mortality, remains poorly understood. We used data from the UK Biobank to combine polygenic risk scores (PRS) for 13 diseases and 12 mortality risk factors into sex-specific composite PRS (cPRS). These cPRS were moderately associated with...

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Identifiers

PMID: 32758451
DOI: 10.1016/j.ajhg.2020.07.002
PMCID: PMC7477009

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