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Article

High resolution mapping of the B cell epitopes of staphylokinase in humans using negative selection of a phage-displayed antigen library.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1998

Jenné S, Brepoels K, Collen D, Jespers L

Abstract excerpt

Staphylokinase (Sak), a 16-kDa protein secreted by Staphylococcus aureus, induces fibrin-specific thrombolysis in patients with thrombotic disorders. However, Sak also elicits high titers of neutralizing Abs that persist for several months and preclude its repeated use in humans. To identify the...

Topics

Amino Acid Substitution
Antibodies, Bacterial
Antigens, Bacterial
Epitope Mapping
Epitopes, B-Lymphocyte
Genetic Variation
Humans
Immunodominant Epitopes
Immunoglobulin G
Inoviridae
Metalloendopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Mutation

Peptide Library

Staphylococcus aureus

Source

Identifiers

PMID: 9743384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9743384-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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High resolution mapping of the B cell epitopes of staphylokinase in humans using negative selection of a phage-displayed antigen library.PMID 9743384Read ↗

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