Article
Construction of a novel Staphylokinase (SAK) mutant with low immunogenicity and its evaluation in rhesus monkey.
International journal of biological macromolecules - 1 Mar 2020
Wang Min, Chen Yao, Fu Wenliang, Zou Minji, Wang Yuanyuan, Xing Weiwei, Wang Jiaxi, Xu Donggang
Abstract excerpt
The heterologous nature of SAK, a thrombolytic drug, elicits high titers of neutralizing antibodies, which limits its clinical use. Here, we aim to establish a SAK mutant with equivalent activity to the wild type but reduced antigenicity, which may allow for multiple injections. Biosun software was used to predict SAK antigenic epitopes, and several main epitopes were modified by gene deletion and mutation. Ten...
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