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Article

Recombinant Staphylokinase Variants With Altered Immunoreactivity

15 Jul 1996

Abstract excerpt

BACKGROUND: Recombinant staphylokinase offers promise for thrombolytic therapy in acute myocardial infarction, but it is immunogenic. Although reduced immunogenicity of heterologous proteinaceous drugs by protein engineering has not previously been reported, an attempt was made to achieve this in staphylokinase by site-specific mutagenesis. METHODS AND RESULTS: Biospecific interaction analysis of a panel of 17...

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PMID: 8674179
DOI: 10.1161/01.cir.94.2.197

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