Article

Open or closed? Exploring the conformational heterogeneity of human plasminogen across multiple resolution scales

2026-07-23

Abstract excerpt

Plasminogen (Plg), the zymogen of the fibrinolytic protease plasmin, is a multidomain, conformationally-rich protein that plays a crucial role in targeted thrombolysis for stroke and heart attack treatments. Yet, the conformational state that affects binding to Plg activators and fibrinolytic activity is rarely validated, contributing to poor reproducibility and failures in drug development. Here, we establish a s...

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Literature Corpus work: 98291e27-716b-5f7b-b63b-a5baabbf9507
DOI: 10.64898/2026.07.23.740275

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