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Article

Staphylokinase Requires NH2-terminal Proteolysis for Plasminogen Activation

1 Feb 1997

Abstract excerpt

Staphylokinase (Sak), a single-chain protein comprising 136 amino acids with NH2-terminal sequence,SSSFDKGKYKKGDDA forms a complex with plasmin, that is endowed with plasminogen activating properties. Plasmin is presumed to process mature (high molecular weight, HMW) Sak to low molecular weight derivatives (LMW-Sak), primarily by hydrolyzing the Lys10-Lys11 peptide bond, but the kinetics of plasminogen activation...

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Identifiers

PMID: 9038231
DOI: 10.1074/jbc.272.9.6067

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Staphylokinase Requires NH2-terminal Proteolysis for Plasminogen ActivationPMID 9038231Read ↗

Role of the N-terminal region of staphylokinase (SAK): evidence for the participation of the N-terminal region of SAK in the enzyme-substrate complex formation.Semantic proximity Read ↗

Structural and functional basis of plasminogen activation by staphylokinase.Semantic proximity Read ↗

Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.Semantic proximity Read ↗

Mutation of lysines in a plasminogen binding region of streptokinase identifies residues important for generating a functional activator complex.Semantic proximity Read ↗

Staphylokinase as a Plasminogen Activator Component in Recombinant Fusion ProteinsSemantic proximity Read ↗

The kringle domains of human plasminogen.Semantic proximity Read ↗

Identification of a new exosite involved in catalytic turnover by the streptokinase-plasmin activator complex during human plasminogen activation.Semantic proximity Read ↗

Activation of human plasminogen by staphylokinase. Direct evidence that preformed plasmin is necessary for activation to occur.Semantic proximity Read ↗

PlasminogenSemantic proximity Read ↗

Functional analysis of the amino- and carboxyl-termini of streptokinase.Semantic proximity Read ↗

Structure-function analysis of the streptokinase amino terminus (residues 1-59).Semantic proximity Read ↗

Investigating the Conformational Flexibility of Staphylokinase Across Multiple Time ScalesSemantic proximity Read ↗

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